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Analysis of single-strand exceptional word symmetry in the human genome: new measures
2014
Biostatistics
Some previous studies suggest the extension of Chargaff 's second rule (the phenomenon of symmetry in a single DNA strand) to long DNA words. However, in random sequences generated under an independent symbol model where complementary nucleotides have equal occurrence probabilities, we expect the phenomenon of symmetry to hold for any word length. In this work, we develop new statistical methods to measure the exceptional symmetry. Exceptional symmetry is a refinement of Chargaff 's second
doi:10.1093/biostatistics/kxu041
pmid:25190514
fatcat:sjivp4fxv5az3a2w6nowuzihdy