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Genetic polymorphism of glutamate-cysteine ligase (GCL) could lead the changes in GCL enzyme activities. These changes could disrupt glutathione synthesis allowing the reduction of glutathione level. Furthermore, the decrease of glutathione level would change the phenotype and lead to the lack of defense against some diseases. The aim of this study was to determine the relationship between genetic polymorphism of the-129C/T promoter region in glutamate-cysteine ligase sub unit catalytic (GCLC)fatcat:re2sabtv45cmhmx5c4ywfrdipq