were followed for application of the ABSTRACT antiviral compounds, which were sprayed Mancino, L. J. C., and Agrios, G. N. 1984. Effects of antiviral compounds on symptoms and as follows: treatment A-2 days and 1 infectivity of cowpea chlorotic mottle virus. Plant Disease 68:219-222. day before inoculation and immediately after inoculation; treatment B-2 days Symptoms of cowpea plants infected with cowpea chlorotic mottle virus (CCMV) were suppressed and 1 day before inoculation, immediately

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... n plants were sprayed with ribavirin, amantadine, formycin, and methisazone but not after inoculation, and 1 day after when sprayed with MBC. 2-Thiouracil sprays increased or decreased symptoms, depending on inoculation; treatment C-immediately time of application. 2-Thiouracil, formycin, and methisazone also caused phytotoxicity on sprayed after inoculation; treatment D-immeplants. Ribavirin reduced and 2-thiouracil increased the infectivity of CCMV in some treatments, whereas the other compounds had little or no effect. Some ribavirin and formycin treatments of diately after inoculation and 1 day after soybean plants reduced CCMV local lesion numbers significantly. All other applications of the inoculation; treatment E-immediately antiviral compounds caused some but statistically nonsignificant reductions in local lesion after inoculation and 1, 2, 3, and 4 days formation. Ribavirin and amantadine did not significantly alter detectable viral antigen after inoculation; and treatment F-1, 3, concentrations in sap from treated, infected cowpea plants as determined by ELISA. 6, and 8 days after inoculation. In each experiment, one flat (20 X 12.5