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Global analysis of epigenetic heterogeneity identifies divergent drivers of esophageal squamous cell carcinoma
[article]
2019
bioRxiv
pre-print
Epigenetic landscapes can shape physiologic and disease phenotypes. We used integrative, high resolution multi-omics methods to characterize the oncogenic drivers of esophageal squamous cell carcinoma (ESCC). We found 98% of CpGs are hypomethylated across the ESCC genome and two-thirds occur in long non-coding (lnc)RNA regions. DNA methylation and epigenetic heterogeneity both coincide with chromosomal topological alterations. Gene body methylation, polycomb repressive complex occupancy, and
doi:10.1101/641357
fatcat:yueijf5iybgpva3sclb6qcvxpu