Various regimens are used for immunosuppression for liver transplantation (LT). Even though steroid is one of the key drugs, it has many adverse effects, especially infection. A steroidfree immunosuppression protocol has been recently adopted at our institute. In this report, we evaluate usability of such protocol. Methods: The study comprised 141 patients who underwent LT from January 2009 until November 2013 excluding the cases with ABO-incompatible transplantation or with steroid

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... on before LT. After February 2011, steroid has been replaced with mycophenolate mofetil in the immunosuppression protocol. We analyzed the rate of bacteremia, acute cellular rejection within 3 months after LT and patients' overall survival between the earlier steroid-containing protocol and latter steroid-free protocol. Result: The incidence of post-transplant bacteremia tended to decrease, but insignificantly (P = 0.086), while rejection tended to occur more frequently, but insignificantly (P = 0.367) after LT under the steroid-free protocol, however, most of rejection cases were controlled by steroid pulse treatment. There was no significant difference in overall survival between both protocols (P = 0.281). Conclusion: Steroid-free immunosuppression could be of value in LT in decreasing risk of bacteremia without the complication of rejection after LT.