Assoziationen zwischen inflammatorischen Parametern und morphologischen Charakteristika des ZNS bei affektiv erkrankten Patienten – Eine experimentelle Studie im Rahmen der MACS-Kohorte –

Julian Glandorf, Medizin, Pfefferle, Petra Ina (Prof. Dr. Dr.)
Psychiatric disorders of the affective spectrum not only cause serious individual suffering, but also tremendous socio-economic costs. Further research of the multifactorial genesis of these illnesses is provided by the DFG funded Marburg-Münster Affective Disorder Cohort Study (MACS). It focuses on the diverse genetical and molecular mechanisms underlying the genesis and maintaining of these disorders. Beside development of new treatment approaches, the research foundation strives to detect
more » ... trives to detect measurable biological parameters as a basis for diagnostical classification or as therapy control. This dissertation pursues the goal of detecting immunological and brain morphometric differences between healthy and ill subjects. Furthermore a statistically significant association between these parameters shall be detected. For this purpose peripheral venal blood of 609 participants of the MACS was incubated with lipopolysaccharide (LPS) and antiCD3/CD28-antibodies. LPS induces a general proinflammatory immune response, whereas antiCD3/CD28 gives rise to a specific T-cell response. The released cytokines were then quantified by a Cytometric Bead Array System (CBA). They reflect the general capacity and responsiveness of the immune system. Additionally, this dissertation incorporates volume data of multiple brain regions measured by a 3-tesla MRI. This data was provided by other members of the MACS. While healthy men and affected men show almost identical immune responses, healthy women show significantly higher concentrations of proinflammatory cytokines (IL1-β, TNF-α, IFN-γ, IL17-α und IL12p70) than their ill counterparts. Brain morphometric differences can be detected at the lateral ventricles, the thalamus, the amygdala, the left nucleus caudatus, the right nucleus accumbens und the left hippocampal region. The interaction factors related to the diagnoses, the age and/or the gender show significant values for these brain regions. Furthermore, in logistic regression model IL10 and TNF-α show significant influence on [...]
doi:10.17192/z2019.0157 fatcat:bnbbk6e6fvbyznpkulle7k5fqa