Immunological studies on lupus nephritis

Yoshinao TARUMI
1980 Okayama Igakkai Zasshi (Journal of Okayama Medical Association)  
C1q, the first component of C1, was isolated from normal human sera according to Thu nild's method. Specific antibody to C1q was produced in rabbits. Fluorescein isothiocyanate (FITC) was labelled on the antibody. Renal tissues from 35 patients with systemic lupus erythematosus (SLE) were stained with FITC labelled antibody to C1q as well as C3, IgG, IgM and IgA. The following results were obtained. 1. Glomerular deposition of C1q was frequently seen in patients who had massive deposition of
more » ... unoglobulins and C3 along the glomerular basement membrane. The distribution of C1q is similar to that of immunoglobulins and C3. 2. Positive Ciq deposition on glomeruli was associated with low levels of serum Ciq and the presence of complement fixing antibody to native DNA. 3. Serial renal biopsy of 15 patients with SLE showed that a marked decrease of C1q de position was observed after steroid therapy. These results indicate that glomerular deposition of C1q is of importance to evaluate the clinical and immunopathological activity of lupus nephritis.
doi:10.4044/joma1947.92.5-6_587 fatcat:cdaba4hzofboxctadt2bzdxzhm