Staphylococcus Aureus (S. aureus) causes community (CA) and hospital-acquired (HA) infections that kills millions of patients every year. It is unclear if Methicillin-resistant Staphylococcus Aureus (MRSA) have higher mortality and complication than Methicillin -susceptible Staphylococcus Aureus (MSSA) infections in CA and HA infections. Methods: This retrospective study included confirmed of cases S. aureus infections, which classified as MSSA or MRSA and CA or HA infections We assessed 30-day

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... mortality, rate of Septic Shock and Acute Renal Injury (AKI) as outcomes measures. Results: Of the total 183 cases included, we found no differences between MRSA and MSSA cases in mortality (P=0.734) and other outcomes. Likewise, CA and HA cases Similar mortality. However, HA cases developed a higher rate of AKI compared to CA cases. We observed this increased rate of AKI only in HA MSSA cases. Conclusion: This study offers a new perspective on HA MSSA as a serious pathogen as MRSA, that requires intervention to prevent its spread. Future research needed to identify new measures for MSSA prevention and investigate whether current MRSA prevention strategies are effective in MSSA. Keywords: Methicillin-resistant; MRSA; MSSA; Saudi Arabia; Staphylococcus aureus