An Effective GCN-based Hierarchical Multi-label classification for Protein Function Prediction [article]

Kyudam Choi, Yurim Lee, Cheongwon Kim, Minsung Yoon
2021 arXiv   pre-print
We propose an effective method to improve Protein Function Prediction (PFP) utilizing hierarchical features of Gene Ontology (GO) terms. Our method consists of a language model for encoding the protein sequence and a Graph Convolutional Network (GCN) for representing GO terms. To reflect the hierarchical structure of GO to GCN, we employ node(GO term)-wise representations containing the whole hierarchical information. Our algorithm shows effectiveness in a large-scale graph by expanding the GO
more » ... raph compared to previous models. Experimental results show that our method outperformed state-of-the-art PFP approaches.
arXiv:2112.02810v1 fatcat:lhxbqku5y5gwhonv4g2sktm37a