1915 The Lancet  
pressure produced by the injections. The average pulse-rate before injection was 134'1, after it 104. The slight fall was attributed to an initial rise caused by apprehension created by the apparatus. The rate and amplitude of the respirations were unaffected. The conclusion was that " strychnine has no effect which justifies its employment as a rapid cardiac stimulant in cases of heart failure." As the evidence that a single dose of strychnine does not benefit heart failure does not prove that
more » ... does not prove that its prolonged use is not beneficial, Dr. Newburgh investigated this point in eight cases of chronic heart failure in which a careful regimen had produced no improvement. Strychnine was then given in doses varying from 0'03 to 0'1 grain and the effect upon the pulse, respiration, urinary excretion, systolic and diastolic pressures was noted. None of the
doi:10.1016/s0140-6736(01)53446-7 fatcat:whfetajlg5frzi4cfauolwseqm