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Combining several ordinal measures in clinical studies
2004
Statistics in Medicine
In medical research, it is rare that a single variable is su cient to represent all relevant aspects of epidemiological risk, genomic activity, adverse events, or clinical response. Since biological systems tend to be neither linear, nor hierarchical in nature, the assumptions of traditional multivariate statistical methods based on the linear model can often not be justiÿed on theoretical grounds. Establishing concept validity through empirical validation is not only problematic, but also time
doi:10.1002/sim.1778
pmid:15122738
fatcat:5563jyonijdjrcrp5xkn4rpcg4