This paper presents an algorithm for improving the segmentation from a semi-automatic artificial neural network (ANN) hippocampus segmentation of co-registered T1-weigthted and T2-weighted MRI data, in which the semi-automatic part is the selection of a boundingbox. Due to the morphological complexity of the hippocampus and the difficulty of separating from adjacent structures, reproducible segmentation using MR imaging is complicated. The grey-level thresholding uses a histogram-based method

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... find robust thresholds. The T1-weighted data is grey-level eroded and dilated to reduce leaking from hippocampal tissue to the surrounding tissues and selecting possible foreground tissue. The method is a 3D approach, it uses 3 × 3 × 3 structure element for the grey-level morphology operations and the algorithms are applied in the three directions, sagittal, axial, and coronal, and the results are then combined together.