A tumor lysis-like syndrome during therapy of visceral leishmaniasis

Evagelos Liberopoulos, George Alexandridis, Moses Elisaf
2002 Annals of Clinical and Laboratory Science  
Reported herein for the first time in the literature is the case of a 41-yr-old woman who developed a tumor lysis-like syndrome, consisting of hyperkalemia, hyperphosphatemia, hyperuricemia, and acute renal insufficiency, soon after the initiation of chemotherapy for severe visceral leishmaniasis with liposomal amphotericin B. Allopurinol therapy, together with iv fluid administration and urine alkalization, resulted in full recovery of the metabolic abnormalities. Awareness of this condition
more » ... of this condition can lead to prophylactic treatment as well as the early recognition and management of susceptible patients.
pmid:12458897 fatcat:phqsjxe6jjfehfeuws7ftip6p4