Optimal Efficacy in Light-Activated Biomedical Systems and Nonlinear Laws versus Linear Beer-Lambert Law and Bunsen-Roscoe Reciprocal Law

Jui-Teng Lin
2018 Open Access Journal of Biomedical Engineering and Biosciences  
Efficacy of light-activated biomedical processes depends on the tissues (media) optical properties, the photosensitizers, and the light parameters such as its wavelength, energy, intensity, pulse-width, repetition rate and the operation modes. Optimal combination of light fluence (energy density), intensity and irradiation time may be achieved via scaling laws. Beer-Lambert law (BLL) and Bunsen-Roscoe law (BRL, for reciprocity rule) are discussed and compared to new nonlinear scaling laws
more » ... ped by coupled equation for light intensity and concentration of the photosensitizers. The linear BLL is limited to simple case, when there is no photosensitizer depletion. Type-II photodynamic therapy efficacy follows the BRL (for the case of no external oxygen supply, with P=0), whereas type-I and type-II (with P>0) follow a non-linear non-BRL.
doi:10.32474/oajbeb.2018.01.000123 fatcat:7jvdsrgqtfhxtojroxq4a33srm