A study of the antimutagenic effects of different extracts of Aloe vera leaf gel and latex using Ames test

Mehrabian, Majd, Jonoubi
2012 Arak Medical University Journal (AMUJ)   unpublished
Nowadays, cancer is one of the main causes of death in the world and mutagens cause death in millions of patients. Noticing the side effects of the drugs used to treat cancer, scientists are looking for drugs with fewer side effects and more therapeutic effects. Accordingly, the number of studies in this field is rapidly increasing. This study was done to evaluate the effects of antimutagenesis of aqueous and alcoholic extracts of A. vera leaf gel and latex by Ames test against the mutagenic
more » ... stance named sodium azid in the presence and absence of microsomal homogenates of rat liver (S9). Materials and Methods:In this experimental study, after preparing different extracts of A. vera gel and latex, the antimutagenic effect of different extracts was assessed by Ames test, within which a mutant strain was grown on a culture containing mutagen substance (NaN3). Antimutagen (A. vera extract) reduced reversed mutation. The difference between the mean number of revertants per plate in relation to the mutagens was analyzed through one-way ANOVA using SPSS software. Results: The results showed that the ethanol extract of latex and aqueous extract of gel had the maximum (91%) and minimum (56%) percentages of inhibition, respectively. Conclusion: This assessment revealed strong antimutagenicity effect for all of the extracts due to the presence of different kinds of antioxidants substances such as various anthraquinones, flavonoids, and vitamins A, C, and E. The maximum inhibition of mutation was observed in ethanol extract of latex. This observation supports the results obtained from the application of microsome mixture as well as those reported by other researchers.