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High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic β Cells
2001
Journal of Biological Chemistry
Glucose-induced insulin secretion from hyperglycemic 90% pancreatectomized rats is markedly impaired, possibly because of loss of  cell differentiation. Association of these changes with  cell hypertrophy, increased mRNA levels of the transcription factor c-Myc, and their complete normalization by phlorizin treatment suggested a link between chronic hyperglycemia, increased c-Myc expression, and altered  cell function. In this study, we tested the effect of hyperglycemia on rat pancreatic
doi:10.1074/jbc.m105020200
pmid:11457846
fatcat:on4ruit3tzaydnj2vzjtmpdwim