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For the last twenty years fragment assembly was dominated by the "overlap -layout -consensus" algorithms that are used in all currently available assembly tools. However, the limits of these algorithms are being tested in the era of genomic sequencing and it is not clear whether they are the best choice for large-scale assemblies. Although the "overlap -layout -consensus" approach proved to be useful in assembling clones, it faces difficulties in genomic assemblies: the existing algorithms makedoi:10.1093/bioinformatics/17.suppl_1.s225 pmid:11473013 fatcat:r7vcy6yhffbezowzs6rexndy6e