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2004) J. Biol. Chem. 279, 53635-53642). Here we have elucidated the fine specificity of CCR5 residues involved in binding and HIV inhibitory potential of C-18. To delineate the regions of CCR5 involved in C-18 binding, we analyzed C-18 inhibition of cells expressing CXCR4/ CCR5 chimeric receptors and CCR5 with a truncated N terminus (⌬2-19). These experiments identified a critical role for the N terminus of CCR5 in C-18 binding and anti-HIV activity. Studies with a large panel of CCR5doi:10.1074/jbc.m500236200 pmid:15975927 fatcat:5oakqqt7uzccdjlzhh7wzxnk74