Estimation of antibodies to mutated citrullinated vimentin in Egyptian patients with chronic hepatitis C virus infection associated with arthropathy
International Journal of Current Research in Medical Sciences
The prevalence of extra hepatic manifestations of chronic HCV infection is more than 74%, among different extra-hepatic manifestations (EHMs) articular involvement is a frequent complication. Clinical picture of HCV related arthropathy varies widely; RA-like HCV related arthropathy can be clinically indistinguishable from recent onset RA, in which articular damage and deformities have not yet occurred. Differentiating patients with HCV related arthropathy from RA patients represents a
... resents a diagnostic and therapeutic challenge. Aim of the work: The study aimed to determine the prevalence of anti-MCV antibodies in HCV-infected patients and to assess the utility of anti-MCV antibodies in distinguishing between patients with RA and those with HCVrelated arthropathy. Patients and Methods: This study was conducted on 75 chronic hepatitis C patients who fulfilling the designed inclusion criteria. The study was carried out in outpatient clinics of Tropical Medicine department and Rheumatology departments Al-Azhar University Hospitals (Al-Hussein & Sayed Galal Hospitals), during the period from March to November 2016. The patients enrolled in the study were classified into three groups: Group (I): Included 25 patients of HCV and Rheumatoid Arthritis, Group (II): Included 25 patients of HCV with articular manifestation. and Group (III): Included 25 patients of HCV without articular manifestation. Results: Seroprevalence of Anti-MCV in GI was positive in 23/25 versus 2/25 seronegative cases while the seroprevalence of Anti-MCV in GII was positive in 2/25 versus 23/25 seronegative cases (P>0.05) and the mean titer of Anti-MCV antibodies was 136.26±113.3 , 14.05±5.1,and 12.89±5.8 in GI,GII,and GIII respectively . The sensitivity and specificity of Anti-MCV was 92% and Diagnostic Accuracy also 92% so Anti-MCV antibodies had higher specificity for diagnosis of RA (p value<0.001). Conclusions: Anti-MCV antibodies may help in differentiating patients with RA from those patients with HCV related arthropathy.