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The canonical Wnt/Wingless pathway is implicated in regulating cell proliferation and cell differentiation of neural stem/progenitor cells. Depending on the context, b-Catenin, a key mediator of the Wnt signaling pathway, may regulate either cell proliferation or differentiation. Here, we show that b-Catenin signaling regulates the differentiation of neural stem/progenitor cells in the presence of the b-Catenin interactor Homeodomain interacting protein kinase-1 gene (Hipk1). On one hand, Hipk1doi:10.1093/cercor/bhr320 pmid:22095214 fatcat:kkboqzn23ver5donkgc7juz54e