Preoperative neutrophil-lymphocyte ratio as a predictor of overall survival in patients with localized renal cell carcinoma

Damian Widz, Przemyslaw Mitura, Pawel Buraczynski, Pawel Plaza, Marek Bar, Michal Cabanek, Grzegorz Nowak, Anna Ostrowska, Krzysztof Bar
2019 Urology Journal  
The neutrophil-to-lymphocyte ratio (NLR), as an indicator of the systemic inflammatory response, predicts adverse outcomes in many malignancies. We investigated its prognostic significance in patients with non-metastatic renal cell carcinoma. We retrospectively evaluated data of 196 consecutive non-metastatic RCC patients who underwent radical or partial nephrectomy between 2010 and 2012 at a single center. Overall survival (OS) was assessed using the Kaplan-Meier method and compared using the
more » ... og-rank test. We applied univariate and multivariate Cox regression models to evaluate the prognostic value of dichotomized NLR for OS. Results: At a median follow up of 68 months, high NLR (? 2,69) correlated with worse survival outcome (P = .006 in log-rank test) and higher tumor stage (P = .035). Univariate and multivariate analysis identified elevated NLR (P = .039), as well as age (P = .002), high Fuhrmann grade (P = .002) and high pathologic T stage (P < .001), as significantly associated with overall survival. In our cohort, an elevated neutrophil-to-lymphocyte ratio is significantly associated with worse OS on univariate and multivariate analysis. Consequently, the NLR is an easily acquired biomarker, which may be useful in pretreatment patient risk stratification.
doi:10.22037/uj.v0i0.4541 pmid:31087321 fatcat:3lzeel3cnzegpbclr6wfutvaxi