Gnetin C, a resveratrol dimer, reduces amyloid-β 1–42 (Aβ42) production and ameliorates Aβ42-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells

Syota SEINO, Takeru KIMOTO, Hidemi YOSHIDA, Kunikazu TANJI, Tomoh MATSUMIYA, Ryo HAYAKARI, Kazuhiko SEYA, Shogo KAWAGUCHI, Kazushi TSURUGA, Hiroshi TANAKA, Tadaatsu IMAIZUMI
2018 Biomedical research  
Accumulation and oligomerization of amyloid-beta (Aβ) peptides have been known to be a potent cause of neurodegenerative diseases such as Alzheimer's disease (AD). To expand the possibilities of preventing AD, we investigated the effects of resveratrol dimers, gnetin C and ε-viniferin, on Aβ 1-42 (Aβ42) production and the reduced cell viability observed after Aβ42 treatment (monomers, 10 μM) in cultured SH-SY5Y human neuroblastoma cells. Among them, addition of gnetin C (20 μM) into the media
more » ... duced Aβ42 production most efficiently. Gnetin C suppressed the expression of β-site amyloid precursor protein-cleaving enzyme-1 (BACE1
doi:10.2220/biomedres.39.105 pmid:29899186 fatcat:3r5gozykznhbxkuomlsvwkg7ry