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The role of DNA double-strand breaks in spontaneous homologous recombination in S. cerevisiae
Homologous recombination (HR) is a source of genomic instability and the loss of heterozygosity in mitotic cells. Since these events pose a severe health risk, it is important to understand the molecular events that cause spontaneous HR. In eukaryotes, high levels of HR are a normal feature of meiosis and result from the induction of a large number of DNA double-strand breaks (DSBs). By analogy, it is generally believed that the rare spontaneous mitotic HR events are due to repair of DNA DSBsdoi:10.1371/journal.pgen.0020194.eor fatcat:nkzavy2fifdjpeuzmwze4vyoyu