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Cyclooxygenase-1 and -2 in human placenta and placental bed after normal and pre-eclamptic pregnancies
1997
Human Reproduction
In pre-eclampsia, the ratio of prostacyclin:thromboxane production rate is decreased favouring the vasoconstrictive thromboxane. One of the rate-limiting steps in prostaglandin synthesis is cyclooxygenase (COX) activity. Therefore, we investigated the expression of COX-1 and COX-2 in human placenta and placental bed. Tissue specimens from the 29th to 40th week of pregnancy were obtained from Caesarean sections after uncomplicated and preeclamptic pregnancies before the onset of labour. COX-1
doi:10.1093/humrep/12.10.2313
pmid:9402302
fatcat:6mqwlz5y7bfmzogroxikegeo64