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Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages
2000
Journal of Endocrinology
Dehydroepiandrosterone (DHEA) is a ubiquitous adrenal hormone with immunomodulatory effects such as inhibition of the production of monokines. Whether DHEA itself or the downstream steroids are the immunomodulatory effector hormones in target cells is not known. In this study, we investigated the conversion of DHEA to downstream steroid hormones in target macrophages. Within 1 day of culture with radiolabeled DHEA, monocyte-derived macrophages converted DHEA to significant amounts of
doi:10.1677/joe.0.1640161
pmid:10657851
fatcat:35i6mrmdb5cineggxa456jksji