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Pharmacokinetic properties of pravastatin in Mexicans: An open-label study in healthy adult volunteers
2005
Current Therapeutic Research
The pharmacokinetic properties of pravastatin, particularly AUC and Cma ~, are variable by population. A description of the pharmacokinetic properties of pravastatin in Mexican mestizos was not found in a search of MEDLINE/ PubMed (key terms: pravastatin, Mexican, and pharmacokinetics; years: 1966-2005). Because Mexicans and Japanese have common ancestors (Mongoloid group), they also have a common gene pool. This gene pool was modified by genetic "bottlenecks" that occurred when these
doi:10.1016/s0011-393x(05)00054-8
fatcat:d6wlrkc7xfh63nzmv32x6xx6x4