Department of Pharmacy, Vikas Group of Institution, Nunna-521 212, Vijayawada Rural, Andhra Pradesh, India E-mail: drbiswamohansahoo@gmail.com Community Health System of South Texas, Edinburg, Texas 78539, USA Department of Pharmaceutical Sciences, Sardar Bhagwan Singh University, Dehradun-248 161, Uttarakhand, India Manuscript received 28 September 2018, accepted 01 November 2018 A series of pyrimidine-2(1H)-one derivative were obtained by multi-component one-pot synthesis under microwave

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... iation. Equimolar quantities of ethylacetoacetate, substituted benzaldehydes and urea undergo condensation followed by cyclizaton in presence of aqueous solution of sodium hydroxide to produce corresponding pyrimidine derivatives. With the help of microwave heating, there is clean reaction with shorter reaction time, environmental-friendly, improved yield as compared to conventional heating method. The structures of the newly synthesized compounds have been established on the basis of their IR, NMR spectral data. These compounds were screened for their anti-inflammatory activity. Some of them were found to possess significant activity as compared to standard drug.