Infectivity of Post-Kala-azar Dermal Leishmaniasis Patients to Sand Flies: Revisiting a Proof of Concept in the Context of the Kala-azar Elimination Program in the Indian Subcontinent

Ricardo Molina, Debashis Ghosh, Eugenia Carrillo, Séverine Monnerat, Caryn Bern, Dinesh Mondal, Jorge Alvar
2017 Clinical Infectious Diseases  
We compared xenodiagnosis with quantitative polymerase chain reaction in skin biopsies from 3 patients with maculopapular or nodular post-kala-azar dermal leishmaniasis (PKDL). All patients infected sand flies. Parasite loads in skin varied from 1428 to 63 058 parasites per microgram. PKDL detection and treatment are important missing components of the kala-azar elimination program.
doi:10.1093/cid/cix245 pmid:28520851 pmcid:PMC5848257 fatcat:kg7takb4zjhwjaf2jwrbggnzie