A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Ectopic SOX9 Mediates Extracellular Matrix Deposition Characteristic of Organ Fibrosis
2008
Journal of Biological Chemistry
Appropriate temporospatial expression of the transcription factor SOX9 is important for normal development of a wide range of organs. Here, we show that when SOX9 is expressed ectopically, target genes become expressed that are associated with disease. Histone deacetylase inhibitors in clinical trials for cancer therapy induced SOX9 expression via enhanced recruitment of nuclear factor Y (NF-Y) to CCAAT elements in the SOX9 proximal promoter. The effect of histone deacetylase inhibitors could
doi:10.1074/jbc.m707390200
pmid:18296708
fatcat:rum3hticivcc7o7acxp7sdi45i