Refractory anemia (RA)

A Cuneo, GL Castoldi
2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology  
Note: This disorder is part of the heterogeneous category of myelodysplastic syndrome (MDS). According to the FAB classification of MDS, RA includes those patients with refractory cytopenia with multilineage dysplasia (RCMD), the latter category having been recognised as a distinct entity by the WHO classification (vide infra). Also, the 5q-syndrome is part of the RA in the FAB classification. In this card, the FAB classification will be used, because the majority of available data on
more » ... c anomalies was derived from studies published before WHO classification. Clinics and pathology Phenotype/cell stem origin RA is a clonal disorder originating from a totipotent stem cell or from a multipotent myeloid progenitor cell, characterized by ineffective hemopoiesis and diserythropoiesis.
doi:10.4267/2042/38054 fatcat:mcvma73vlvds3h2mfaui3amwjm