To present MR imaging findings of intracranial lesions in systemic lupus erythem atosus (SLE) , a retrospective study was performed o n MR images of 33 SLE pa tients with neurologic symptoms and signs. MR imaging was performed on either a 0.5T (21 patient s) or 2.0T unit ( 12 patients) , u sin g T1-weighted , proton-density-weighted, and T2-weighted spin echo sequences in all patients . 1n seven patients, post-contrast T 1-weighted images were also obtained after administration of gadopentetate

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... dimeglumine. T he main MR findings consisted of fo cal. lesion s suggesting ischemia/infarct (15 patients) , diffu se brain atrophy (8) , and findings associated with infection (4). The MR findin gs were norm al in 11 patien ts (33 % ). The focal lesion s suggesting ischemialinfarcts presumably secondary to vasculiti s were distributed in the cortex or subcortical white matter (7 patients) , d eep periventrκul a r white matter (3) , or in both areas (5). Most ofthe fo callesions were multiple and small in size. The findings associated with infection were variable and included communicating hydrocephalus , m eningeal enhancem ent , granuloma , etc. MR findings of SLE were non-specific and therefore clinical correlation is needed when evalating SLE in MR . Index Words: Brain , M agnetic R eson ance lnm agin g 10. 1214 Brain , Lupus Erythematous 10. 6 1 Brain , vasculitis 10 .62 Brain , infarction 10.78 서 론 전신성 홍반성 낭창 ( syste mi c lupus erythematosus: SLE) 은 자가변역 질환 ( autoimmune di sease) 으로서 드 * 충북대학교 의과대학 방사선과학교실 물지 않게 혈관염 . 2차적 감염등에 의해 뇌병변이 발생한 다. 임상적으로 경련, 편두통, 시력장애, 국소신경증상, 정신이상 등의 임상 증세를 나타내 는데 감별진단으로는 약물유도현상 ( drug -induced phenomenon, 특히 스테로