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Exploring the substrate specificity of sialyltransferases
1997
Pure and Applied Chemistry
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Twelve trisaccharide derivatives designed for detailed exploration of the acceptor specificity of sialyltransferases involved in the biosynthesis of N-glycans have been synthesized. These compounds include P and analogues containing structural variants of Dgalactose. All trisaccharides were obtained by condensation of suitably modified glycosyl donors with a single disaccharide acceptor, thus limitating the number of reaction steps required. After deprotection, the compounds were employed to
doi:10.1351/pac199769030537
fatcat:o3ihgh35wbeuxkzi7umrrbwuky