Insulin Binding to Erythrocytes in Chronic Glucocorticoid Deficiency
Hypoadrenocorticismにおける赤血球インスリン受容体結合能

Keigo YASUDA, Noriyuki TAKEDA, Tomiko HORIYA, Tatsuyuki IMAI, Koji YAMADA, Makoto HAYASHI, Shinobu GOTO, Kaori AOYAMA, Kiyoshi MIURA, Kotaro NAGAI, Shinobu TANAHASHI
1987 Folia Endocrinologica Japonica  
The effect of chronic glucocorticoid deficiency on insulin binding to erythrocyte was evaluated in 2 cases of ACTH deficiency, 2 of Sheehan's syndrome and a case of Addison's disease before and after the replacement therapy with cortisone acetate. 75 gram oral glucose tolerance test (OGTT) was also performed. Mean fasting plasma glucose (FPG) and insulin (FIRI) before (70.2mg/d1, 3.6pU/m1) and after (75.4 mg/dl, 7.8pU/ml) therapy were significantly lower than those in normal control (97.0mg/d1,
more » ... 12.0µU/ml). The ratio of FIRI/FPG before and after treatment were also significantly lower than that in control subjects. Glucose areas during OGTT before and after treatment were not different from that in control subjects. However, insulin area before treatment was significantly lower than that in control group. There were significant increases in FIRI/FPG and insulin area, but not in FPG and glucose area before and after treatment. Insulin binding to erythrocytes before treatment (11.9 1.1%, mean ± SD) was greater than that in normal subjects (7.7 ± 1.9%, n=19, p<0.05). It was significantly decreased and 第63巻 第3号
doi:10.1507/endocrine1927.63.3_239 pmid:3038631 fatcat:l4b6uzxlkzdopnjigtxeu7wp4y