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Phylogenetic Clustering of Genes Reveals Shared Evolutionary Trajectories and Putative Gene Functions
2018
Genome Biology and Evolution
Homologous genes in prokaryotes can be described using phylogenetic profiles which summarize their patterns of presence or absence across a set of genomes. Phylogenetic profiles have been used for nearly twenty years to cluster genes based on measures such as the Euclidean distance between profile vectors. However, most approaches do not take into account the phylogenetic relationships amongst the profiled genomes, and overrepresentation of certain taxonomic groups (i.e., pathogenic species
doi:10.1093/gbe/evy178
pmid:30137329
fatcat:up4m4sxyuvgu3a2zhyk3zvhoga