We present a study of the chemistry toward 294 dense cores in 12 molecular clumps, using data obtained from the ALMA Survey of 70 μm dark High-mass clumps in Early Stages. We identified 97 protostellar cores and 197 prestellar core candidates, based on the detection of outflows and molecular transitions of high upper-energy levels (E u /k > 45 K). The detection rate of the N2D+ emission toward the protostellar cores is 38%, which is higher than 9% for the prestellar cores, indicating that N2D+

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... oes not exclusively trace prestellar cores. The detection rates of the DCO+ emission are 35% for the prestellar cores and 49% for the protostellar cores, which are higher than those for N2D+, implying that DCO+ appears more frequently than N2D+ in both prestellar and protostellar cores. Both the N2D+ and DCO+ abundances appear to decrease from the prestellar to the protostellar stage. The DCN, C2D, and 13CS emission lines are rarely seen in the dense cores of early evolutionary phases. The detection rate of the H2CO emission toward dense cores is 52%, three times higher than that for CH3OH (17%). In addition, the H2CO detection rate, abundance, line intensities, and line widths increase with the core evolutionary status, suggesting that the H2CO line emission is sensitive to protostellar activity.