Asthma phenotypes in childhood

Matea Deliu, Danielle Belgrave, Matthew Sperrin, Iain Buchan, Adnan Custovic
2016 Expert Review of Clinical Immunology  
Asthma is no longer thought of as a single disease, but rather a collection of varying symptoms expressing different disease patterns. One of the ongoing challenges is understanding the underlying pathophysiological mechanisms that may be responsible for the varying responses to treatment. Areas Covered: This review provides an overview of our current understanding of the asthma phenotype concept in childhood and describes key findings from both conventional and data-driven methods. Expert
more » ... ntary: With the vast amounts of data generated from cohorts, there is hope that we can elucidate distinct pathophysiological mechanisms, or endotypes. In return, this would lead to better patient stratification and disease management, thereby providing true personalised medicine.
doi:10.1080/1744666x.2017.1257940 pmid:27817211 fatcat:56u2owtepzgkvjcwlpecuohmzq