Sheet-beam geometry for in vivo fluorescent x-ray computed tomography: proof-of-concept experiment in molecular imaging

Qingkai Huo, Tetsuya Yuasa, Takao Akatsuka, Tohoru Takeda, Jin Wu, Thet-Thet-Lwin, Kazuyuki Hyodo, F. Avraham Dilmanian
<span title="2008-10-24">2008</span> <i title="The Optical Society"> <a target="_blank" rel="noopener" href="" style="color: black;">Optics Letters</a> </i> &nbsp;
We propose a fluorescent x-ray computed tomography (CT) method using an array of detectors with an incident sheet-beam, aimed at providing molecular imaging with high sensitivity and good spatial resolution. In this study, we prove the feasibility of this concept and investigate its imaging properties including spatial and contrast resolutions and quantitativeness, by imaging an acrylic phantom and a normal mouse brain, using a preliminary imaging system with monochromatic synchrotron x rays.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="">doi:10.1364/ol.33.002494</a> <a target="_blank" rel="external noopener" href="">pmid:18978898</a> <a target="_blank" rel="external noopener" href="">fatcat:ecjlky2vc5dajnh4katxewju6i</a> </span>
<a target="_blank" rel="noopener" href="" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href=""> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / </button> </a>