HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects: TABLE 1

Kelley M. Argraves, W. Scott Argraves
2007 Journal of Lipid Research  
The lysosphingolipid sphingosine 1-phosphate (S1P) is a component of HDL. Findings from a growing number of studies indicate that S1P is a mediator of many of the cardiovascular effects of HDL, including the ability to promote vasodilation, vasoconstriction, and angiogenesis, protect against ischemia/reperfusion injury, and inhibit/ reverse atherosclerosis. These latter cardioprotective effects are being shown to involve the S1P-mediated suppression of inflammatory processes, including
more » ... including reduction of the endothelial expression of monocyte and lymphocyte adhesion molecules, decreased recruitment of polymorphonuclear cells to sites of infarction, and blocking of cardiomyocyte apoptosis after myocardial infarction. This review article summarizes the evidence that S1P as a component of HDL serves to regulate vascular cell and lymphocyte behaviors associated with cardiovascular (patho)physiology.-Argraves, K. M., and W. S. Argraves. HDL serves as a S1P signaling platform mediating a multitude of cardiovascular effects. J. Lipid Res.
doi:10.1194/jlr.r700011-jlr200 pmid:17698855 fatcat:7bnjbgj5avfjdhkmgrqwaw35ty