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Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine
2018
Frontiers in Bioengineering and Biotechnology
The specialization of cartilage cells, or chondrogenic differentiation, is an intricate and meticulously regulated process that plays a vital role in both bone formation and cartilage regeneration. Understanding the molecular regulation of this process might help to identify key regulatory factors that can serve as potential therapeutic targets, or that might improve the development of qualitative and robust skeletal tissue engineering approaches. However, each gene involved in this process is
doi:10.3389/fbioe.2018.00165
pmid:30483498
pmcid:PMC6243751
fatcat:6mcrreicojewdk4nyr6pljmimy