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Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis

Daniela PELCLOV^|^Aacute;, Zdenka FENCLOV^|^Aacute;, ^|^Scaron;tep^|^aacute;nka VLCKOV^|^Aacute;, Jindri^|^scaron;ka LEBEDOV^|^Aacute;, Kamila SYSLOV^|^Aacute;, Ondrej PECHA, Jarom^|^iacute;r BEL^|^Aacute;CEK, Tom^|^aacute;^|^scaron; NAVR^|^Aacute;TIL, Marek KUZMA, Petr KACER
2012 Industrial Health  

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Leukotrienes (LTs) are involved in the pathogenesis of lung fibrosis and were increased in exhaled breath condensate (EBC) of the patients with pneumoconiosis. However the possible influence of extra-pulmonary disorders on the EBC markers is not known. Therefore in parallel with EBC, LTs' levels in the plasma and urine were measured in patients with pneumoconiosis (45 × asbestos exposure, 37 × silica exposure) and in 27 controls. Individual LTs B4, C4, D4 and E4 were measured by liquid
more » ... raphy − electrospray ionization − tandem mass spectrometry (LC-ESI-MS/MS). In EBC, LT D4 and LT E4 were increased in both groups of patients (p<0.001 and p<0.05), comparing with the controls. Both LT B4 and cysteinyl LTs were elevated in asbestosexposed subjects (p<0.05). Asbestosis with more severe radiological signs (s1/s2-t3/u2) and lung functions impairment has shown higher cysteinyl LTs and LT C4 in the EBC (p<0.05) than mild asbestosis (s1/s0-s1/s1). In addition, in the subjects with asbestosis, cysteinyl LTs in EBC correlated with TLC (−0.313, p<0.05) and TLCO/Hb (−0.307, p<0.05), and LT C4 with TLC (−0.358, p<0.05). In pneumoconioses, EBC appears the most useful from the 3 fluids studied.
doi:10.2486/indhealth.ms1274 pmid:22785421 fatcat:ivkk33r2ovegvgblom6gek5p5u
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Daniela PELCLOV^|^Aacute;, Zdenka FENCLOV^|^Aacute;, ^|^Scaron;tep^|^aacute;nka VLCKOV^|^Aacute;, Jindri^|^scaron;ka LEBEDOV^|^Aacute;, Kamila SYSLOV^|^Aacute;, Ondrej PECHA, Jarom^|^iacute;r BEL^|^Aacute;CEK, Tom^|^aacute;^|^scaron; NAVR^|^Aacute;TIL, Marek KUZMA, Petr KACER. "Leukotrienes B4, C4, D4 and E4 in the Exhaled Breath Condensate (EBC), Blood and Urine in Patients with Pneumoconiosis." Industrial Health 50.4 (2012) 299-306