P56 Effects of hypoxia on angiogenesis and proliferation – Correlation with tumour response in patients with cervical cancer treated with combined radiation and carbogen–nicotinamide

S. Mutya Sekarutami, S. Gondhowiardjo, F. Aziz, N.C. Sregar, A. Harahap
2011 EJC Supplements  
We used 3-deoxy-3-18 F-fluorothymidine (FLT) PET-CT to delineate biological tumour volume in thoracic oesophageal carcinoma, for a treatment planning simulation. We compared results with that of 18 F-fluorodeoxyglucose (FDG) PET-CT, on the basis of dosimetric analysis. Methods: 22 patients with oesophageal squamous-cell carcinoma detected by FLT and FDG PET-CT were enrolled. We used the treatment planning system to compare hypothetical treatment plans based on the optimal threshold for standard
more » ... uptake value of FLT and FDG PET-CT. We compared parameters in dosevolume histograms of the two groups, planning fields in similar directions and ensuring the prescribed dose line surrounded 95% of the target volume. Findings: Gross tumour volume, clinical target volume, and planning target volume were less with FLT than with FDG PET-CT imaging. The conformity index and homogeneity index did not differ significantly between FLT and FDG PET-CT treatment planning. The difference in V 20 of bilateral lung, V 40 of heart, and maximum dose received by the spinal cord did not differ significantly between FLT and FDG. Values for mean lung dose, V 5 , V 10 , V 30 , V 40 , and V 50 of bilateral lung, and mean heart dose and V 30 of heart were significantly lower with FLT PET-CT based planning than with FDG PET-CT (t = -5.442 to À2.637, p < 0.05). Interpretation: Treatment planning based on FLT PET-CT had potential benefits for some organs at risk, such as lungs and heart.
doi:10.1016/j.ejcsup.2011.02.057 fatcat:wsd7gtdfbvbfve24zqplo7y7jq