Effects of the myostatin F94L substitution on beef traits1

A. K. Esmailizadeh, C. D. K. Bottema, G. S. Sellick, A. P. Verbyla, C. A. Morris, N. G. Cullen, W. S. Pitchford
2008 Journal of Animal Science  
This study investigated the effects of a SNP in the myostatin gene (MSTN or growth differentiation factor 8, GDF8) on birth, growth, carcass, and beef quality traits in Australia (Aust.) and New Zealand (NZ). The SNP is a cytosine to adenine transversion in exon 1, causing an amino acid substitution of leucine for phenylalanine 94 (F94L). The experiment used crosses between the Jersey and Limousin breeds, with the design being a backcross using first-cross bulls of Jersey × Limousin or Limousin
more » ... × Jersey breeding, mated to Jersey and Limousin cows. Progeny were genotyped for the myostatin SNP and phenotyped in Aust., with finishing on feedlot (366 calves, over 3 birth years) and in NZ with finishing on pasture (416 calves, over 2 birth years). The effect of the F94L allele (A allele) on birth and growth traits was not significant. The F94L allele in Limousin backcross calves was associated with an increase in meat weight (7.3 and 5.9% of the trait mean in Aust. and NZ, respectively, P < 0.001), and a reduction in fat depth (−13.9 and −18.7% of the trait means
doi:10.2527/jas.2007-0589 pmid:18245504 fatcat:tixh62c77zgcbi772ci67yuz5y