Mucus and Ciliated Cells of Human Lung: Splitting Strategies for Particle Methods and 3D Stokes Flows

R. Chatelin, P. Poncet, A. Didier, M. Murris-Espin, D. Anne-Archard, M. Thiriet
2015 Procedia IUTAM  
This proceeding is introducing a fractional step algorithm for diffusion-transport allowing computation of flows with sharp variations of viscosity. This splitting also allows to perform transport with Lagrangian methods and diffusion with Eulerian methods, using hybrid grid-particle formulation. This splitting algorithm is globally second order. It is applied to computation of mucus mobility in human lungs, where epithelium ciliated cells are beating. A sufficient mobility is required to have
more » ... ealthy configurations. Our goal is to study the dependency of mucus mobility with respect to its viscosity in order to investigate mechanisms involved in pathologies such as cystic fibrosis.
doi:10.1016/j.piutam.2015.11.012 fatcat:k67bpf7v55ft5eimiy4gsa5m7e