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Spontaneous Mutation Accumulation Studies in Evolutionary Genetics
Annual Review of Ecology, Evolution and Systematics
Mutation accumulation (MA) experiments, in which mutations are allowed to drift to fixation in inbred lines, have been a principal way of studying the rates and properties of new spontaneous mutations. Phenotypic assays of MA lines inform us about the nature of new mutational variation for quantitative traits and provide estimates of the genomic rate and the distribution of effects of new mutations. Parameter estimates compared for a range of species suggest that the genomic mutation ratedoi:10.1146/annurev.ecolsys.39.110707.173437 fatcat:lshowdqikvg5bk5g7vs5miugiy