A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression
2016
Science Translational Medicine
Lung cancer is the most common cause of cancer deaths. The expression of the transcription factor C/EBPa (CCAAT/ enhancer binding protein a) is frequently lost in non-small cell lung cancer, but the mechanisms by which C/EBPa suppresses tumor formation are not fully understood. In addition, no pharmacological therapy is available to specifically target C/EBPa expression. We discovered a subset of pulmonary adenocarcinoma patients in whom negative/low C/EBPa expression and positive expression of
doi:10.1126/scitranslmed.aad6066
pmid:27488898
fatcat:pjz4j6flfjd3rdo5ktlywdmeo4