Calcium bilirubinate sludge causes early onset of congenital biliary dilatation: a report of two cases

Shoko Kato, Kenitiro Kaneko, Nozomi Matsushita, Shintaro Kurahashi, Takaaki Osawa, Tatsuki Matsumura, Takuya Saito, Yasuyuki Fukami, Shunichiro Komatsu, Tsuyoshi Sano
2021 Surgical Case Reports  
Background Symptomatic congenital biliary dilatation (CBD) during early infancy is always characterized by cystic dilation of the common bile duct with a narrow segment connecting the pancreatic duct. Case presentation In two consecutive infants with a prenatal diagnosis of CBD, we found that biliary sludge had formed in the cyst upon the appearance of symptoms including acholic stool and hypertransaminasemia. Infrared absorption spectrometry revealed that the sludge consisted of calcium
more » ... inate. Conclusion We suggest that overproduction of bilirubin by neonatal hemolysis causes sedimentation of bilirubin calcium, resulting in obstruction of the narrow segment and development of symptoms.
doi:10.1186/s40792-021-01175-x pmid:33851282 fatcat:2p6qvskqd5ewphcszkglp44ivq