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Intratumoral regions of low extracellular pH and low nutrition are common features of solid tumors. Although cancer cells normally die when they are removed from their environment, a small population of cells survive. In the present study, the subline LNCaP-F10, of the prostate cancer cell line LNCaP, was isolated and its low pH/low nutrient-resistant properties were examined. LNCaP-F10 cells were grown under low-pH/ low-nutrient conditions, which caused cell death of the LNCaP cells. The celldoi:10.3892/or.2012.2039 pmid:22992840 fatcat:7ovocgortrgczckybewreq4psq