Spinal cord injury (SCI) commonly associated with neuropathic pain, which affect large population. Thus, presented investigation evaluates the beneficial effect of epifriedelinol against SCI associated neuropathic pain. SCI injury was induced in rats by clip-compression and rats treated epifriedelinol 100 and 200 mg/kg i.p., for 21 days after the induction of SCI. effect of epifriedelinol was assessed on neuropathic pain by mechanical allodynia and locomotor function. Level of inflammatory

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... ines were assessed in the neuronal tissue using enzyme linked immunosorbent assay (ELISA) and expression of caspase-3 and Bcl2 protein were assessed by western blot assay. Data of investigation reveals that epifriedelinol reduces mechanical allodynia in SCI injured rats, moreover it also improves locomotor function in SCI injured rats. There was significant decrease in level of interleukin-1β (IL-1β), IL-6 and TNF-α in the neuronal tissues of epifriedelinol treated group than negative control group. Moreover, treatment with epifriedelinol ameliorates the altered expression of caspase 3, Bcl2 and GluN1 and level of glutamate in neuronal tissue of SCI injured rats. In conclusion, data reveals that epifriedelinol treatment protects neuropathic pain associated with spinal cord injury by downregulating the N-methyl-D-aspartate (NMDA) receptor function.