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Activation of thecyclin D1Gene by the E1A-associated Protein p300 through AP-1 Inhibits Cellular Apoptosis
Journal of Biological Chemistry
The adenovirus E1A protein interferes with regulators of apoptosis and growth by physically interacting with cell cycle regulatory proteins including the retinoblastoma tumor suppressor protein and the coactivator proteins p300/CBP (where CBP is the CREB-binding protein). The p300/CBP proteins occupy a pivotal role in regulating mitogenic signaling and apoptosis. The mechanisms by which cell cycle control genes are directly regulated by p300 remain to be determined. The cyclin D1 gene, which isdoi:10.1074/jbc.274.48.34186 pmid:10567390 fatcat:wqsyf2sfkbbjhcdqrf55ncf7mu