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Rational discovery of small molecule inhibitor targeting invasion and tumor growth
[post]
2022
unpublished
Rational targeting of proteins involved in controlling cancer cell behavior with small bioactive compounds can accelerate anti-cancer drug discovery. We report the identification of a new small molecule compound inhibitor of the FGFR adaptor protein FRS2. Pharmacophore-based computational screening combined with functional, biophysical, and structural binding analyses, led to the identification of low-molecular weight ligands that interact with the PTB domain of FRS2. By assessing the
doi:10.21203/rs.3.rs-1359115/v1
fatcat:hidxqgj6gvaerprfjq7lhaijai